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In response to genotoxic chemotherapy exposure, TNBC cells adaptively upregulate pyrimidine synthesis to increase the production of nucleotides necessary for DNA repair, whereas using leflunomide, a clinically approved inhibitor of de novo pyrimidine synthesis for the management of rheumatoid arthritis, sensitizes TNBC cells to chemotherapy and causes significant tumor regression when used in combination with doxorubicin 115

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Use of complementary and alternative medicine among the ethnic elderly